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VON WILLEBRAND DISEASE (VWD) (3)
Willebrand s disease is the most common bleeding disorder. It concerns a group of various types of von Willebrand disease. vWF functional or quantitative deficiency allows characterizing von Willebrand disease, which can be classed into 3 types: - Type 1: vWD is characterized by a partial quantitative deficit of vWF (most frequently). - Type 2: vWD is characterized by an abnormal vWF adhesion activity. It is divided into 4
subtypes: 2A, 2B, 2M and 2N, depending on the multimers functional abnormality. - Type 3: vWD is characterized by a severe quantitative vWF deficiency.
vWF deficiencies can be associated with various other pathologies, thus constituting an acquired von Willebrand disease. When vascular endothelium is affected, the vWF concentration can be increased in relation to inflammatory processes.
LIAPHEN™ vWF:Ag Measurement of von Willebrand Factor Antigen (vWF: Ag), in human citrated plasma, with a latex turbidimetric assay.
REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.
LIAPHEN™ vWF:Ag Liquid and Ready to use
CE-IVD 120206 R1: 4 x 5 mL BIOPHEN™
Plasma Calibrator
222101
BIOPHEN™ Normal Control Plasma
BIOPHEN™ Abnormal Control Plasma
223201
223301 R2: 4 x 6 mL
ZYMUTEST™ vWF Measurement of von Willebrand Factor (vWF) in human plasma, by Elisa.
COMPLETE SOLUTION Product Name RS Ref. Presentation
ZYMUTEST™ vWF CE-IVD RK030A 96 tests
ZYMUTEST™ vWF:CBA Measurement of human von Willebrand Factor (vWF) Collagen Binding Activity (CBA) in human activated plasma.
COMPLETE SOLUTION Product Name RS Ref. Presentation ZYMUTEST™
vWF:CBA CE-IVD RK038A 96 tests
Research
vWF Deficient Plasma For any study or research protocol where a source of human vWF deficient plasma is required.
COMPLETE SOLUTION Product Name RS Ref. Presentation vWF Deficient
Plasma RUO DP150K 6 x 1 mL
OTHER BLEEDING DISORDERS
FACTOR XII (FXII) (1,3) Most affected individuals with FXII deficiency are asymptomatic and have rarely a mild tendency to bleed. However, they can show an impaired fibrinolysis, which can expose them to thrombosis.
Since bleeding time is usually normal, diagnosis is characterized by a prolonged activated partial thromboplastin time (aPTT) test. A specific FXII assay helps to confirm the diagnosis.
Factor XII Deficient Plasma Used in combination with CEPHEN™ (ref. CK511K CK512K CK515K CK515L) to measure FXII clotting activity in human citrated plasma.
REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.
Factor XII Deficient Plasma
CE-IVD DP080A 1 x 1 mL BIOPHEN™
Plasma Calibrator
222101
BIOPHEN™ Normal Control Plasma
BIOPHEN™ Abnormal Control Plasma
223201
223301 DP080K 6 x 1 mL
FACTOR XI (FXI) (2) FXI deficiency is a very rare disease. It is an inherited genetic disorder, affecting both women and men. Bleeding has a variable expression in the affected kindreds, it is not always dependent on the residual FXI concentration.
Factor XI Deficient Plasma Used in combination with CEPHEN™ (ref. CK511K CK512K CK515K CK515L) to measure FXI clotting activity in human citrated plasma.
REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.
Factor XI Deficient Plasma
CE-IVD DP070A 1 x 1 mL BIOPHEN™
Plasma Calibrator
222101
BIOPHEN™ Normal Control Plasma
BIOPHEN™ Abnormal Control Plasma
223201
223301DP070K 6 x 1 mL
FACTOR VII (FVII) (3) Autosomal recessive inheritance.
FVII can be deficient in presence of vitamin K deficiency (hepatic diseases, primary biliary cirrhosis, deficiency in new-borns, antibiotherapy, ), vitamin K antagonists (dicoumarol therapy, ), isolated deficiencies of FVII or accelerated clotting factor consumption (DIC).
(3) www.hemophilia.org (1) cf Dedicated intructions for use - (2) www.afh.asso.fr - (3) www.hemophilia.org