Elevated fibrinogen concentrations are observed in inflammation and have also been considered as a risk factor for cardiovascular disease and thrombosis.
Hypofibrinogenemia can be present in patients with fibrinogen deficiency or dysfunction (abnormal protein), and is also associated with severe liver diseases, or excessive consumption (Disseminated Intravascular Coagulation (DIC)).
Numerous variants of fibrinogen have been described, and are associated to asymptomatic cases or hypofibrinogenemia, with clinical manifestations of bleeding, or thrombosis (resulting from an impaired fibrinolysis).


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