von Willebrand Disease (vWD)*

Willebrand's disease is the most common bleeding disorder. It concerns a group of various types of von Willebrand disease. vWF functional or quantitative deficiency allows characterizing von Willebrand disease, which can be classed into 3 types:
   • Type 1: vWD is characterized by a partial quantitative deficit of vWF (most frequently).
   • Type 2: vWD is characterized by an abnormal vWF adhesion activity. It is divided into 4 subtypes: 2A, 2B, 2M and 2N, depending on the multimers functional abnormality.
   •Type 3: vWD is characterized by a severe quantitative vWF deficiency.

vWF deficiencies can be associated with various other pathologies, thus constituting an acquired von Willebrand disease. When vascular endothelium is affected, the vWF concentration can be increased in relation to inflammatory processes.


* www.hemophilia.org