Other Bleeding Disorders


Most affected individuals with FXII deficiency are asymptomatic and have rarely a mild tendency to bleed. However, they can show an impaired fibrinolysis, which can expose them to thrombosis.
Since bleeding time is usually normal, diagnosis is characterized by a prolonged activated partial thromboplastin time (aPTT) test. A specific FXII assay helps to confirm the diagnosis.


FXI deficiency is a very rare disease. It is an inherited genetic disorder, affecting both women and men. Bleeding has a variable expression in the affected kindreds, it is not always dependent on the residual FXI concentration.


Autosomal recessive inheritance.
FVII can be deficient in presence of vitamin K deficiency (hepatic diseases, primary biliary cirrhosis, deficiency in new-borns, antibiotherapy, …), vitamin K antagonists (dicoumarol therapy, ...), isolated deficiencies of FVII or accelerated clotting factor consumption (DIC).


No description for this category


Autosomal recessive inheritance.
FX deficiency is extremely rare.
People with mild FX deficiency experience easy bruising, nose or mouth bleeds, and bleeding after trauma or surgery. Symptoms for patients with severe FX deficiency include excessive umbilical cord bleeding, joint bleeds, intramuscular bleeds, and a high risk of intracranial hemorrhage in the first weeks of life.


Autosomal recessive inheritance.
Prothrombin deficiency is a rare hereditary coagulation disorder.
Symptoms include excessive umbilical cord bleeding, easy bruising, frequent nosebleeds and hemorrhaging after surgery or trauma. Women with FII deficiency experience menorrhagia, heavy menstrual bleeding, and postpartum hemorrhage after childbirth. Dysprothrombinemia results from a protein abnormality, which affects prothrombin clotting activity. Hypoprothrombinemia occurs when prothrombin concentration is decreased.


Autosomal recessive inheritance.
FV is deficient in presence of congenital or acquired FV deficiencies, hepatic disorders or accelerated clotting factor consumption (DIC).
High levels of FV are risk factors for venous thrombosis.


Autosomal recessive inheritance.
Umbilical cord bleeding is common in FXIII deficiency.
Some patients sustain a spontaneous intracranial hemorrhage, a brain bleed, which is the leading cause of mortality. Other symptoms of FXIII deficiency include bruising, nose and mouth bleeds, muscle bleeds and delayed bleeding after surgery.
Women can experience menorrhagia, long, heavy menstrual periods, and repeat miscarriages.
Men with FXIII deficiency may show signs of infertility.
Acquired FXIII deficiency can be observed in presence of autoantibodies.